Article

Kinetic co-evolutionary models predict the temporal emergence of HIV resistance mutations under drug selection pressure

2022-12-02

Abstract excerpt

Drug resistance in human immunodeficiency virus (HIV) is a pervasive problem that affects the lives of millions of people worldwide. Although records of drug-resistant mutations (DRMs) have been extensively tabulated within public repositories, our understanding of the evolutionary kinetics of DRMs and how they evolve together remains limited. Epistasis, the interactions between a DRM and other residues in HIV pro...

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Literature Corpus work: 8142f40b-4cc9-5fcb-9b03-b34ea8ec040a
DOI: 10.1101/2022.11.30.518575

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