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Article

Contingency and Entrenchment of Drug-Resistance Mutations in HIV Viral Proteins.

The journal of physical chemistry. B - 22 Dec 2022

Choudhuri Indrani, Biswas Avik, Haldane Allan, Levy Ronald M

Abstract excerpt

The ability of HIV-1 to rapidly mutate leads to antiretroviral therapy (ART) failure among infected patients. Drug-resistance mutations (DRMs), which cause a fitness penalty to intrinsic viral fitness, are compensated by accessory mutations with favorable epistatic interactions which cause an evolutionary trapping effect, but the kinetics of this overall process has not been well characterized. Here, using a...

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Identifiers

PMID: 36493468
DOI: 10.1021/acs.jpcb.2c06123
PMCID: PMC9841799

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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