Article

Evolutionary Sequence and Structural Basis for the Epistatic Origins of Drug Resistance in HIV

2025-05-02

Abstract excerpt

The emergence of drug resistance in the human immunodeficiency virus (HIV) remains a formidable challenge to the long-term efficacy of antiretroviral therapy (ART). A growing body of evidence highlights the critical role of epistasis, the dependence of mutational effects on the sequence context, in shaping the fitness landscape of HIV under ART-induced selection pressure. However, the biophysical origins of the ep...

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Literature Corpus work: 368066ce-4081-534e-8d6c-cbd95362a0d0
DOI: 10.1101/2025.04.30.651576

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