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Article

Inference of Epistatic Effects Leading to Entrenchment and Drug Resistance in HIV-1 Protease.

Molecular biology and evolution - 1 Jun 2017

Flynn William F, Haldane Allan, Torbett Bruce E, Levy Ronald M

Abstract excerpt

Understanding the complex mutation patterns that give rise to drug resistant viral strains provides a foundation for developing more effective treatment strategies for HIV/AIDS. Multiple sequence alignments of drug-experienced HIV-1 protease sequences contain networks of many pair correlations which can be used to build a (Potts) Hamiltonian model of these mutation patterns. Using this Hamiltonian model, we...

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Share to Computer Simulation
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Sequence Alignment

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Identifiers

PMID: 28369521
DOI: 10.1093/molbev/msx095
PMCID: PMC5435099

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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