Article

Forecasting drug resistant HIV protease evolution

2025-04-04

Abstract excerpt

<h4>ABSTRACT</h4> Protease inhibitors (PIs) target the protease (PR) enzyme to suppress viral replication. Their efficacy in human immunodeficiency virus treatment is compromised by the emergence of drug-resistant strains. Therefore, forecasting drug-resistance during viral evolution would help in the design of effective treatment strategies. We develop a probabilistic large-deviation model to infer epistatic int...

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Literature Corpus work: 4d8f27af-fcb1-5ba4-89e0-e40295587c0c
DOI: 10.1101/2025.03.31.646462

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