Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A Darwinian model for the evolution of drug resistance to long-acting PrEP during an early HIV infection.

PloS one - 1 Jan 2026

Gurski Katharine, Kang Yeona, Ma Yanping

Abstract excerpt

Predicting the evolution of drug resistance remains a central challenge in HIV prevention and treatment. Evolutionary trade-offs, i.e., the fitness costs of resistance, shift as drug-selective pressure changes, a complexity amplified by fluctuating drug concentrations during long-acting prophylaxis. We develop a Darwinian evolutionary game theory model of early HIV infection under bimonthly pre-exposure...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Anti-HIV Agents
Share to Drug Resistance, Viral
Share to Evolution, Molecular

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to HIV Infections

Share to Models, Biological

Share to Mutation

Share to Pyridones

Source

Open in PubMed Open full text

Identifiers

PMID: 42623409
DOI: 10.1371/journal.pone.0355833
PMCID: PMC13492818

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A Darwinian model for the evolution of drug resistance to long-acting PrEP during an early HIV infection.PMID 42623409Read ↗

Kinetic co-evolutionary models predict the temporal emergence of HIV resistance mutations under drug selection pressureSemantic proximity Read ↗

Kinetic coevolutionary models predict the temporal emergence of HIV-1 resistance mutations under drug selection pressure.Semantic proximity Read ↗

Antiretroviral dynamics determines HIV evolution and predicts therapy outcome.Semantic proximity Read ↗

Computational models of HIV-1 resistance to gene therapy elucidate therapy design principles.Semantic proximity Read ↗

Pre-existence and emergence of drug resistance in a generalized model of intra-host viral dynamics.Semantic proximity Read ↗

Contingency and Entrenchment of Drug-Resistance Mutations in HIV Viral Proteins.Semantic proximity Read ↗

Understanding patterns of HIV multi-drug resistance through models of temporal and spatial drug heterogeneity.Semantic proximity Read ↗

Understanding patterns of HIV multi-drug resistance through models of temporal and spatial drug heterogeneitySemantic proximity Read ↗

Epistasis and entrenchment of drug resistance in HIV-1 subtype BSemantic proximity Read ↗

Phenotypic Heterogeneity Facilitates Survival While Hindering the Evolution of Drug Resistance Due to Intraspecific CompetitionSemantic proximity Read ↗

Pharmacokinetics, pharmacodynamics, efficacy and drug resistance selection of injectable long-acting lenacapavir pre-exposure prophylaxis (PrEP) against HIVSemantic proximity Read ↗

Timing the emergence of resistance to anti-HIV drugs with large genetic barriers.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.