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Article

Temporal Evolution of Drug Resistance to HIV Integrase Inhibitors.

Viruses - 8 May 2026

Choudhuri Indrani, Olvera Jocelyn G, Biswas Avik, Haldane Allan, Levy Ronald M, Lyumkis Dmitry

Abstract excerpt

HIV-1 integrase (IN) strand transfer inhibitors (INSTIs) are central to modern antiretroviral therapy (ART) because of their high potency and durable effect on viral suppression. However, drug resistance mutations (DRMs) within HIV-1 IN emerge, which can compromise long-term treatment efficacy. Many distinct DRMs that arise under INSTI therapy have been extensively tabulated in public repositories and literature....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 42198743
DOI: 10.3390/v18050540
PMCID: PMC13211648

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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