Forecasting drug resistant HIV protease evolution.

Abstract excerpt

Protease inhibitors (PIs) target the protease (PR) enzyme to suppress viral replication. Their efficacy in human immunodeficiency virus treatment is compromised by the emergence of drug-resistant strains. Therefore, forecasting drug-resistance during viral evolution would help in the design of effective treatment strategies. To this end, we develop a framework that bridges two distinct data sets. First, we train...

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• Computer Simulation
• Drug Resistance, Viral
• HIV-1
• HIV Infections
• HIV Protease
• Computational Biology