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Article

Kinetic coevolutionary models predict the temporal emergence of HIV-1 resistance mutations under drug selection pressure.

Proceedings of the National Academy of Sciences of the United States of America - 9 Apr 2024

Biswas Avik, Choudhuri Indrani, Arnold Eddy, Lyumkis Dmitry, Haldane Allan, Levy Ronald M

Abstract excerpt

Drug resistance in HIV type 1 (HIV-1) is a pervasive problem that affects the lives of millions of people worldwide. Although records of drug-resistant mutations (DRMs) have been extensively tabulated within public repositories, our understanding of the evolutionary kinetics of DRMs and how they evolve together remains limited. Epistasis, the interaction between a DRM and other residues in HIV-1 protein...

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Identifiers

PMID: 38557187
DOI: 10.1073/pnas.2316662121
PMCID: PMC11009627

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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