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Article

Epistasis and entrenchment of drug resistance in HIV-1 subtype B

8 Oct 2019

Abstract excerpt

The development of drug resistance in HIV is the result of primary mutations whose effects on viral fitness depend on the entire genetic background, a phenomenon called 'epistasis'. Based on protein sequences derived from drug-experienced patients in the Stanford HIV database, we use a co-evolutionary (Potts) Hamiltonian model to provide direct confirmation of epistasis involving many simultaneous mutations....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 31591964
DOI: 10.7554/elife.50524

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