Article

Female specific erosion of allelic fidelity in aged CD8 memory T cells

2026-08-28

Abstract excerpt

The molecular mechanisms by which sex and age remodel the mammalian immune system remain poorly understood. Here, we show at single-allele and single-cell resolution that the inactive X chromosome (Xi) is subject to cell-type-specific erosion of its transcriptional fidelity with ageing. Single-cell multiomics analysis in mice revealed this phenotype to be concentrated in aged CD8 memory T cells, where greater Xi t...

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Literature Corpus work: 8094bcbd-1ff3-5fa4-975e-b2ab4ab09891
DOI: 10.64898/2026.08.27.747566

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