Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Impaired dynamic X-chromosome inactivation maintenance in T cells is a feature of spontaneous murine SLE that is exacerbated in female-biased models

1 Jul 2023

Abstract excerpt

OBJECTIVE: Systemic lupus erythematosus (SLE) is a highly female-biased systemic autoimmune disease, but the molecular basis for this female bias remains incompletely elucidated. B and T lymphocytes from patients with SLE and female-biased mouse models of SLE exhibit features of epigenetic dysregulation on the X chromosome which may contribute to this strong female bias. We therefore examined the fidelity of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
Share to Systemic Lupus Erythematosus Research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to T-cell and B-cell Immunology

Source

Identifiers

PMID: 37399593
DOI: 10.1016/j.jaut.2023.103084

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Impaired dynamic X-chromosome inactivation maintenance in T cells is a feature of spontaneous murine SLE that is exacerbated in female-biased modelsPMID 37399593Read ↗

Female mice with a Xist deletion in B cells can develop lupus-associated phenotypes.Semantic proximity Read ↗

The dynamic epigenetic regulation of the inactive X chromosome in healthy human B cells is dysregulated in lupus patientsSemantic proximity Read ↗

The dynamic epigenetic regulation of the inactive X chromosome in healthy human B cells is dysregulated in lupus patients.Semantic proximity Read ↗

Female-bias in systemic lupus erythematosus: How much is the X chromosome to blame?Semantic proximity Read ↗

<i>Xist</i> Deletion in B Cells Results in Systemic Lupus Erythematosus PhenotypesSemantic proximity Read ↗

The molecular underpinnings of female predominance in lupus.Semantic proximity Read ↗

Skewed allelic expression on X chromosome associated with aberrant expression of XIST on systemic lupus erythematosus lymphocytes.Semantic proximity Read ↗

Loss of epigenetic modifications on the inactive X chromosome and sex-biased gene expression profiles in B cells from NZB/W F1 mice with lupus-like diseaseSemantic proximity Read ↗

Altered X-chromosome inactivation predisposes to autoimmunitySemantic proximity Read ↗

Female Bias in Systemic Lupus Erythematosus is Associated with the Differential Expression of X-Linked Toll-Like Receptor 8Semantic proximity Read ↗

Diversity of Epigenetic Features of the Inactive X-Chromosome in NK Cells, Dendritic Cells, and Macrophages.Semantic proximity Read ↗

The XIST lncRNA is a sex-specific reservoir of TLR7 ligands in SLESemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.