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Article

The dynamic epigenetic regulation of the inactive X chromosome in healthy human B cells is dysregulated in lupus patients.

Proceedings of the National Academy of Sciences of the United States of America - 15 Jun 2021

Pyfrom Sarah, Paneru Bam, Knox James J, Cancro Michael P, Posso Sylvia, Buckner Jane H, Anguera Montserrat C

Abstract excerpt

Systemic lupus erythematous (SLE) is a female-predominant disease characterized by autoimmune B cells and pathogenic autoantibody production. Individuals with two or more X chromosomes are at increased risk for SLE, suggesting that X-linked genes contribute to the observed sex bias of this disease. To normalize X-linked gene expression between sexes, one X in female cells is randomly selected for transcriptional...

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Share to Chromosomes, Human, X
Share to Heterochromatin

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Methylation

Share to RNA, Long Noncoding

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Share to X Chromosome Inactivation

Source

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Identifiers

PMID: 34103397
DOI: 10.1073/pnas.2024624118
PMCID: PMC8214693

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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