Article

Lineage-specific X chromosome inactivation escape and skew underlie sex-biased immune gene dosage and deleterious variant exposure

2026-08-31

Abstract excerpt

The X chromosome carries an unusually high density of immune genes and is a major contributor to sex differences in immune function and autoimmune diseases. In females, X-chromosome inactivation (XCI) has two major functional consequences: it shapes X-linked gene dosage through XCI escape and determines the cellular exposure of heterozygous X-linked variants through XCI skew. Yet because XCI creates a mosaic of ce...

Identifiers and source

Literature Corpus work: fd18a520-2345-5946-8f71-b446008cc23a
DOI: 10.64898/2026.08.26.739472

Open publication

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