Article

The dynamic epigenetic regulation of the inactive X chromosome in healthy human B cells is dysregulated in lupus patients

2020-11-27

Abstract excerpt

<h4>ABSTRACT</h4> Systemic lupus erythematous (SLE) is a female-predominant disease characterized by autoimmune B cells and pathogenic autoantibody production. Individuals with two or more X chromosomes are at increased risk for SLE, suggesting that X-linked genes contribute to the observed sex-bias of this disease. To normalize X-linked gene expression between sexes, one X in female cells is randomly selected fo...

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Literature Corpus work: dfcbfe23-c556-57a6-a33e-787414d03641
DOI: 10.1101/2020.11.25.399022

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