Article
Aging increases cell-to-cell transcriptional variability upon immune stimulation.
Science (New York, N.Y.) - 31 Mar 2017
Martinez-Jimenez Celia Pilar, Eling Nils, Chen Hung-Chang, Vallejos Catalina A, Kolodziejczyk Aleksandra A, Connor Frances, Stojic Lovorka, Rayner Timothy F, Stubbington Michael J T, Teichmann Sarah A, de la Roche Maike, Marioni John C, Odom Duncan T
Abstract excerpt
Aging is characterized by progressive loss of physiological and cellular functions, but the molecular basis of this decline remains unclear. We explored how aging affects transcriptional dynamics using single-cell RNA sequencing of unstimulated and stimulated naïve and effector memory CD4+ T cells from young and old mice from two divergent species. In young animals, immunological activation drives a conserved...
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