Article

Altered X-chromosome inactivation predisposes to autoimmunity

2023-04-21

Abstract excerpt

In mammals, males and females show marked differences in immune responses. Males are globally more sensitive to infectious diseases while females are more susceptible to systemic autoimmunity. X-chromosome inactivation (XCI), the epigenetic mechanism that ensures the silencing of one X in females, may participate in these sex-biases. Here, we perturbed the expression of the trigger of XCI, the non-coding RNA Xist...

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Literature Corpus work: f2a59a38-7182-5758-8171-83bb8a171c60
DOI: 10.1101/2023.04.20.537662

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