Article

B cell-specific XIST complex enforces X-inactivation and restrains atypical B cells

2021-01-04

Abstract excerpt

<h4>SUMMARY</h4> The long noncoding RNA (lncRNA) XIST establishes X chromosome inactivation (XCI) in female cells in early development and thereafter is thought to be largely dispensable. Here we show XIST is continually required in adult human B cells to silence a subset of X-linked immune genes such as TLR7 . XIST-dependent genes lack promoter DNA methylation and require continual XIST-dependent histone deacet...

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Literature Corpus work: 127d2194-307d-53d9-824f-893196be0ee0
DOI: 10.1101/2021.01.03.425167

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