Article

An adaptive Epithelial-Mesenchymal Transition Program Enables Basal Epithelial Cells to Bypass Stress-Induced Stasis and Contributes to Metaplastic Breast Cancer Progenitor State

2024-09-27

Abstract excerpt

<title>Abstract</title> <p><bold>Background:</bold> Human mammary epithelial cell (HMEC) cultures encounter a stress-associated barrier termed stasis, during which most cells adopt a senescence-like phenotype. From these cultures, rare variants emerge from the basal epithelial population, re-initiating growth. Variants exhibit pre-malignant properties, including an aberrant epigenetic program that enables continu...

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Literature Corpus work: 807f5cfb-0817-5f5b-b9fb-b9b9308ca45b
DOI: 10.21203/rs.3.rs-4980285/v1

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