Epithelial-mesenchymal transition in carcinoma: navigating phenotypic states to target resistance and metastasis.

Abstract excerpt

Epithelial-mesenchymal transition (EMT), historically described as a binary morphological change from an epithelium to a mesenchymal state, no longer adequately accounts for carcinoma cell phenotypes observed in patients. Single-cell sequencing, spatial-omics, and lineage tracing converge on a different picture as carcinoma cells rarely undergo a unidirectional transition ending as sarcoma-like cells. Instead,...

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