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Interrogation of Phenotypic Plasticity between Epithelial and Mesenchymal States in Breast Cancer

21 Jun 2019

Abstract excerpt

Dynamic interconversions between transitional epithelial and mesenchymal states underpin the epithelial mesenchymal plasticity (EMP) seen in some carcinoma cell systems. We have delineated epithelial and mesenchymal subpopulations existing within the PMC42-LA breast cancer cell line by their EpCAM expression. These purified but phenotypically plastic states, EpCAMHigh (epithelial) and EpCAMLow (mesenchymal), have...

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PMID: 31234417
DOI: 10.3390/jcm8060893

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