Article
Epithelial-mesenchymal transition and cancer stem cells: a dangerously dynamic duo in breast cancer progression
1 Feb 2011
Abstract excerpt
Aberrant activation of a latent embryonic program - known as the epithelial-mesenchymal transition (EMT) - can endow cancer cells with the migratory and invasive capabilities associated with metastatic competence. The induction of EMT entails the loss of epithelial characteristics and the de novo acquisition of a mesenchymal phenotype. In breast cancer, the EMT state has been associated with cancer stem cell...
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