Article
Epithelial mesenchymal transition traits in human breast cancer cell lines parallel the CD44(hi/)CD24 (lo/-) stem cell phenotype in human breast cancer.
Journal of mammary gland biology and neoplasia - 1 Jun 2010
Blick Tony, Hugo Honor, Widodo Edwin, Waltham Mark, Pinto Cletus, Mani Sendurai A, Weinberg Robert A, Neve Richard M, Lenburg Marc E, Thompson Erik W
Abstract excerpt
We review here the recently emerging relationship between epithelial-mesenchymal transition (EMT) and breast cancer stem cells (BCSC), and provide analyses of published data on human breast cancer cell lines, supporting their utility as a model for the EMT/BCSC state. Genome-wide transcriptional profiling of these cell lines has confirmed the existence of a subgroup with mesenchymal tendencies and enhanced...
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