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Article

Cell state plasticity, stem cells, EMT, and the generation of intra-tumoral heterogeneity

11 Apr 2017

Abstract excerpt

Cellular heterogeneity in cancer represents a significant challenge. In order to develop effective and lasting therapies, it is essential to understand the source of this heterogeneity, and its role in tumor progression and therapy resistance. Here, we consider not only genetic and epigenetic mechanisms, but also inflammation and cell state reprogramming in creating tumor heterogeneity. We discuss similarities...

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PMID: 28649654
DOI: 10.1038/s41523-017-0012-z

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