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Article

Resistance to mesenchymal reprogramming sustains clonal propagation in metastatic breast cancer

30 May 2023

Abstract excerpt

The acquisition of mesenchymal traits is considered a hallmark of breast cancer progression. However, the functional relevance of epithelial-to-mesenchymal transition (EMT) remains controversial and context dependent. Here, we isolate epithelial and mesenchymal populations from human breast cancer metastatic biopsies and assess their functional potential in vivo. Strikingly, progressively decreasing epithelial...

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Identifiers

PMID: 37257449
DOI: 10.1016/j.celrep.2023.112533

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