Article
Fluctuating environment causes neoplastic transition and epithelial-mesenchymal plasticity in human cells
2026-07-31
Abstract excerpt
<title>Abstract</title> <p> How environmental selective pressures contribute to the emergence of a neoplastic tumorigenic state, remains incompletely understood. Here we show that the immortalized non-tumorigenic breast epithelial cell line (MCF10A) develops neoplastic clones under fluctuating conditions in-vitro that mimic the harsh tumor microenvironment. Long-term evolutionary experiments and genomic landscap...
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Identifiers and source
- Literature Corpus work
- fee341de-3b1d-59ea-be24-fc4aec7651a9
- DOI
- 10.21203/rs.3.rs-10094171/v1