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Harnessing Carcinoma Cell Plasticity Mediated by TGF-β Signaling

6 Jul 2021

Abstract excerpt

Epithelial cell plasticity, a hallmark of carcinoma progression, results in local and distant cancer dissemination. Carcinoma cell plasticity can be achieved through epithelial-mesenchymal transition (EMT), with cells positioned seemingly indiscriminately across the spectrum of EMT phenotypes. Different degrees of plasticity are achieved by transcriptional regulation and feedback-loops, which confer carcinoma...

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PMID: 34298613
DOI: 10.3390/cancers13143397

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