Article

Genetic barcoding of individual cells links cancer evolutionary trajectories and prognostic outcomes

2025-12-02

Abstract excerpt

Intratumoural heterogeneity (ITH) reflects cancer progression, by integrating clonal dynamics, cell plasticity, and metastatic potential of malignant cells. Defining the origins and evolutionary trajectories of tumour cells is central to preventing tumour growth and dissemination, yet significant gaps in knowledge persist. Here, we used an original single cell resolution lineage tracing system to investigate how I...

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Literature Corpus work: 78420edb-9d06-5d64-acb6-7b7bb1021e7d
DOI: 10.64898/2025.12.01.691488

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