Article

MHC*IMP – Imputation of Alleles for Genes in the Major Histocompatibility Complex

2020-01-25

Abstract excerpt

We report the development of MHC*IMP, a method for imputing non-classical HLA and other genes in the human Major Histocompatibility Complex (MHC). We created a reference panel for 25 genes in the MHC using allele calls from Whole Genome Sequencing data, combined with SNP data for the same individuals. We used this to construct an allele imputation model, MHC*IMP, for each gene. Cross-validation showed that MHC*IMP...

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Literature Corpus work: 802f388a-8bb3-5d85-a086-61a5116d0d0c
DOI: 10.1101/2020.01.24.919191

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