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HLA-IMPUTER: an easy to use web application for HLA imputation and association analysis using population-specific reference panels.

Bioinformatics (Oxford, England) - 1 Apr 2019

Shen Jiangshan J, Yang Chao, Wang Yong-Fei, Wang Ting-You, Guo Mengbiao, Lau Yu Lung, Zhang Xuejun, Sheng Yujun, Yang Wanling

Abstract excerpt

SUMMARY: HLA allele imputation from SNP genotypes has become increasingly useful, but its accuracy is heavily dependent on the reference panels used. HLA-IMPUTER implements HIBAG algorithm for HLA imputation with different population specific reference panels, including a new Han Chinese reference panel derived from 10 689 samples. We provide a convenient platform for researchers to impute HLA alleles and perform...

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PMID: 30169743
DOI: 10.1093/bioinformatics/bty730

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