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Article

Accurate imputation of human leukocyte antigens with CookHLA.

Nature communications - 24 Feb 2021

Cook Seungho, Choi Wanson, Lim Hyunjoon, Luo Yang, Kim Kunhee, Jia Xiaoming, Raychaudhuri Soumya, Han Buhm

Abstract excerpt

The recent development of imputation methods enabled the prediction of human leukocyte antigen (HLA) alleles from intergenic SNP data, allowing studies to fine-map HLA for immune phenotypes. Here we report an accurate HLA imputation method, CookHLA, which has superior imputation accuracy compared to previous methods. CookHLA differs from other approaches in that it locally embeds prediction markers into highly...

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Identifiers

PMID: 33627654
DOI: 10.1038/s41467-021-21541-5
PMCID: PMC7904773

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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