Article
HLA*IMP--an integrated framework for imputing classical HLA alleles from SNP genotypes.
Bioinformatics (Oxford, England) - 1 Apr 2011
Dilthey Alexander T, Moutsianas Loukas, Leslie Stephen, McVean Gil
Abstract excerpt
MOTIVATION: Genetic variation at classical HLA alleles influences many phenotypes, including susceptibility to autoimmune disease, resistance to pathogens and the risk of adverse drug reactions. However, classical HLA typing methods are often prohibitively expensive for large-scale studies. We previously described a method for imputing classical alleles from linked SNP genotype data. Here, we present a...
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