Article
A multi-ethnic reference panel to impute HLA classical and non-classical class I alleles in admixed samples: Testing imputation accuracy in an admixed sample from Brazil.
HLA - 1 Jun 2024
Silva Nayane S B, Bourguiba-Hachemi Sonia, Ciriaco Viviane A O, Knorst Stefan H Y, Carmo Ramon T, Masotti Cibele, Meyer Diogo, Naslavsky Michel S, Duarte Yeda A O, Zatz Mayana, Gourraud Pierre-Antoine, Limou Sophie, Castelli Erick C, Vince Nicolas
Abstract excerpt
The MHC class I region contains crucial genes for the innate and adaptive immune response, playing a key role in susceptibility to many autoimmune and infectious diseases. Genome-wide association studies have identified numerous disease-associated SNPs within this region. However, these associations do not fully capture the immune-biological relevance of specific HLA alleles. HLA imputation techniques may...
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