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Article

HLA imputation and its application to genetic and molecular fine-mapping of the MHC region in autoimmune diseases.

Seminars in immunopathology - 1 Jan 2022

Naito Tatsuhiko, Okada Yukinori

Abstract excerpt

Variations of human leukocyte antigen (HLA) genes in the major histocompatibility complex region (MHC) significantly affect the risk of various diseases, especially autoimmune diseases. Fine-mapping of causal variants in this region was challenging due to the difficulty in sequencing and its inapplicability to large cohorts. Thus, HLA imputation, a method to infer HLA types from regional single nucleotide...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34786601
DOI: 10.1007/s00281-021-00901-9
PMCID: PMC8837514

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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