Article
Imputation of KIR Types from SNP Variation Data.
American journal of human genetics - 1 Oct 2015
Vukcevic Damjan, Traherne James A, Næss Sigrid, Ellinghaus Eva, Kamatani Yoichiro, Dilthey Alexander, Lathrop Mark, Karlsen Tom H, Franke Andre, Moffatt Miriam, Cookson William, Trowsdale John, McVean Gil, Sawcer Stephen, Leslie Stephen
Abstract excerpt
Large population studies of immune system genes are essential for characterizing their role in diseases, including autoimmune conditions. Of key interest are a group of genes encoding the killer cell immunoglobulin-like receptors (KIRs), which have known and hypothesized roles in autoimmune diseases, resistance to viruses, reproductive conditions, and cancer. These genes are highly polymorphic, which makes typing...
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