Article
Multi-population classical HLA type imputation.
PLoS computational biology - 1 Jan 2013
Dilthey Alexander, Leslie Stephen, Moutsianas Loukas, Shen Judong, Cox Charles, Nelson Matthew R, McVean Gil
Abstract excerpt
Statistical imputation of classical HLA alleles in case-control studies has become established as a valuable tool for identifying and fine-mapping signals of disease association in the MHC. Imputation into diverse populations has, however, remained challenging, mainly because of the additional haplotypic heterogeneity introduced by combining reference panels of different sources. We present an HLA type imputation...
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