The cis-regulatory effect of an Alzheimer's disease-associated poly-T locus on expression of TOMM40 and apolipoprotein E genes.

doi:10.1016/j.jalz.2013.08.280

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Article

The cis-regulatory effect of an Alzheimer's disease-associated poly-T locus on expression of TOMM40 and apolipoprotein E genes.

Alzheimer's & dementia : the journal of the Alzheimer's Association - 1 Sept 2014

Linnertz Colton, Anderson Lauren, Gottschalk William, Crenshaw Donna, Lutz Michael W, Allen Jawara, Saith Sunita, Mihovilovic Mirta, Burke James R, Welsh-Bohmer Kathleen A, Roses Allen D, Chiba-Falek Ornit

Abstract excerpt

BACKGROUND: We investigated the genomic region spanning the Translocase of the Outer Mitochondrial Membrane 40-kD (TOMM40) and Apolipoprotein E (APOE) genes, that has been associated with the risk and age of onset of late-onset Alzheimer's disease (LOAD) to determine whether a highly polymorphic, intronic poly-T within this region (rs10524523; hereafter, 523) affects expression of the APOE and TOMM40 genes....

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Identifiers

PMID: 24439168
DOI: 10.1016/j.jalz.2013.08.280
PMCID: PMC4098029

Genes

APOE
TOMM40

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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