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Article

The APOE-TOMM40 Humanized Mouse Model: Characterization of Age, Sex, and PolyT Variant Effects on Gene Expression.

Journal of Alzheimer's disease : JAD - 1 Jan 2023

Gottschalk William K, Mahon Scott, Hodgson Dellila, Barrera Julio, Hill Delaney, Wei Angela, Kumar Manish, Dai Kathy, Anderson Lauren, Mihovilovic Mirta, Lutz Michael W, Chiba-Falek Ornit

Abstract excerpt

BACKGROUND: The human chromosome 19q13.32 is a gene rich region and has been associated with multiple phenotypes, including late onset Alzheimer's disease (LOAD) and other age-related conditions. OBJECTIVE: Here we developed the first humanized mouse model that contains the entire TOMM40 and APOE genes with all intronic and intergenic sequences including the upstream and downstream regions. Thus, the mouse model...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 37458041
DOI: 10.3233/JAD-230451
PMCID: PMC10733864

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