Biochemical studies of poly-T variants in the Alzheimer's disease associated TOMM40 gene.

doi:10.3233/JAD-2012-120580

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Biochemical studies of poly-T variants in the Alzheimer's disease associated TOMM40 gene.

Journal of Alzheimer's disease : JAD - 1 Jan 2012

Hedskog Louise, Brohede Jesper, Wiehager Birgitta, Pinho Catarina Moreira, Revathikumar Priya, Lilius Lena, Glaser Elzbieta, Graff Caroline, Karlström Helena, Ankarcrona Maria

Abstract excerpt

The apolipoprotein E (APOE) gene remains the most strongly established risk factor for late onset Alzheimer's disease (LOAD). Recently the gene, TOMM40, which is in linkage disequilibrium with APOE, was identified to be associated with LOAD in genome-wide association studies. One of the identified polymorphisms in TOMM40 is rs10524523, which is located in intron 6 and composed of thymidine repeats varying between...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alzheimer Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cells, Cultured

Share to Databases, Factual

Share to Fibroblasts

Share to TOMM40 gene

Share to Genetic Variation

Share to Membrane Transport Proteins

Share to Mitochondrial Precursor Protein Import Complex Proteins

Source

Open in PubMed

Identifiers

PMID: 22596268
DOI: 10.3233/JAD-2012-120580

Genes

APOE
TOMM40

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Biochemical studies of poly-T variants in the Alzheimer's disease associated TOMM40 gene.PMID 22596268Read ↗

The cis-regulatory effect of an Alzheimer's disease-associated poly-T locus on expression of TOMM40 and apolipoprotein E genes.Semantic proximity Read ↗

TOMM40 rs10524523 polymorphism's role in late-onset Alzheimer's disease and in longevity.Semantic proximity Read ↗

Association and expression analyses with single-nucleotide polymorphisms in TOMM40 in Alzheimer disease.Semantic proximity Read ↗

The effects of the TOMM40 poly-T alleles on Alzheimer's disease phenotypes.Semantic proximity Read ↗

An inherited variable poly-T repeat genotype in TOMM40 in Alzheimer disease.Semantic proximity Read ↗

A TOMM40 variable-length polymorphism predicts the age of late-onset Alzheimer's disease.Semantic proximity Read ↗

Associations between TOMM40 Poly-T Repeat Variants and Dementia in Cases with Parkinsonism.Semantic proximity Read ↗

A TOMM40 poly-T variant modulates gene expression and is associated with vocabulary ability and decline in nonpathologic aging.Semantic proximity Read ↗

Characterization of the poly-T variant in the TOMM40 gene in diverse populations.Semantic proximity Read ↗

TOMM40 intron 6 poly-T length, age at onset, and neuropathology of AD in individuals with APOE ε3/ε3.Semantic proximity Read ↗

TOMM40 poly-T Variants and Cerebrospinal Fluid Amyloid Beta Levels in the ElderlySemantic proximity Read ↗

TOMM40 polymorphisms in Italian Alzheimer's disease and frontotemporal dementia patients.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.