The 677C > T variant in methylenetetrahydrofolate reductase causes morphological and functional cerebrovascular deficits in mice.

doi:10.1177/0271678X221122644

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Article

The 677C > T variant in methylenetetrahydrofolate reductase causes morphological and functional cerebrovascular deficits in mice.

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism - 1 Dec 2022

Reagan Alaina M, Christensen Karen E, Graham Leah C, Bedwell Amanda A, Eldridge Kierra, Speedy Rachael, Figueiredo Lucas L, Persohn Scott C, Bottiglieri Teodoro, Nho Kwangsik, Sasner Michael, Territo Paul R, Rozen Rima, Howell Gareth R

Abstract excerpt

Vascular contributions to cognitive impairment and dementia (VCID) particularly Alzheimer's disease and related dementias (ADRDs) are increasing; however, mechanisms driving cerebrovascular decline are poorly understood. Methylenetetrahydrofolate reductase (MTHFR) is a critical enzyme in the folate and methionine cycles. Variants in MTHFR, notably 677 C > T, are associated with dementias, but no mouse model...

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PMID: 36050860
DOI: 10.1177/0271678X221122644
PMCID: PMC9670012

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