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Article

Alzheimer’s genes in microglia: a risk worth investigating

20 Nov 2023

Abstract excerpt

Despite expressing many key risk genes, the role of microglia in late-onset Alzheimer's disease pathophysiology is somewhat ambiguous, with various phenotypes reported to be either harmful or protective. Herein, we review some key findings from clinical and animal model investigations, discussing the role of microglial genetics in mediating perturbations from homeostasis. We note that impairment to protective...

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PMID: 37986179
DOI: 10.1186/s13024-023-00679-4

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