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The <i>677C>T</i> variant in <i>methylenetetrahydrofolate reductase</i> causes morphological and functional cerebrovascular deficits in mice

2021-12-16

Abstract excerpt

Vascular contributions to cognitive impairment and dementia (VCID) particularly Alzheimer’s disease and related dementias (ADRDs) are increasing; however, mechanisms driving cerebrovascular decline are poorly understood. Methylenetetrahydrofolate reductase (MTHFR) is a critical enzyme in the folate and methionine cycles. Variants in MTHFR , notably 677C>T , are associated with dementias, but no mouse model exist...

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Literature Corpus work
20cfad3d-719d-5604-ab30-9a1fa0c60626
DOI
10.1101/2021.12.16.472805
Open publication

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The <i>677C>T</i> variant in <i>methylenetetrahydrofolate reductase</i> causes morphological and functional cerebrovascular deficits in miceDOI 10.1101/2021.12.16.472805
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