Article
The Histone Acetyltransferase Mst2 Protects Active Chromatin from Epigenetic Silencing by Acetylating the Ubiquitin Ligase Brl1.
Molecular cell - 20 Jul 2017
Flury Valentin, Georgescu Paula Raluca, Iesmantavicius Vytautas, Shimada Yukiko, Kuzdere Tahsin, Braun Sigurd, Bühler Marc
Abstract excerpt
Faithful propagation of functionally distinct chromatin states is crucial for maintaining cellular identity, and its breakdown can lead to diseases such as cancer. Whereas mechanisms that sustain repressed states have been intensely studied, regulatory circuits that protect active chromatin from inactivating signals are not well understood. Here we report a positive feedback loop that preserves the...
Topics
- Acetylation
- Chromatin Assembly and Disassembly
- Euchromatin
- Feedback, Physiological
- Gene Expression Regulation, Fungal
- Gene Silencing
- Heterochromatin
- Histone Acetyltransferases
- Histones
- Membrane Proteins