BRD2 bridges TFIID and histone acetylation to promote transcriptional initiation

Abstract excerpt

Members of the bromodomain and extraterminal domain (BET) protein family play a central role in transcription by RNA Polymerase II (Pol II). Small-molecule inhibitors that block interaction between BET bromodomains and acetylated histones have been developed to achieve therapeutic benefit. However, the BET protein BRD4 does not require bromodomains to perform its major transcriptional elongation function, and the...

Topics

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• Adaptive Immunity
• CCCTC-Binding Factor
• Chromosomal Proteins, Non-Histone
• Cohesins
• Interferon Regulatory Factors
• RNA Polymerase II
• STAT3 Transcription Factor
• Th17 Cells

Identifiers and source

Literature Corpus work

05d450f1-732c-5fda-9f31-d900d8d6ca4c

DOI

10.1101/2025.09.20.676678