Article

Dysregulation of synaptic transcripts underlies network abnormalities in ALS patient-derived motor neurons

2024-05-31

Abstract excerpt

Amyotrophic lateral sclerosis (ALS) is characterized by dysfunction and loss of upper and lower motor neurons. Several studies have identified structural and functional alterations in the motor neurons before the manifestation of symptoms, yet the underlying cause of such alterations and how they contribute to the progressive degeneration of affected motor neuron networks remain unclear. Importantly, the short and...

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Literature Corpus work: 688eaad5-9092-58bd-a8f5-43d2563817a8
DOI: 10.1101/2024.05.29.596436

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