Article

<i>APOE4</i> impacts cortical neurodevelopment and alters network formation in human brain organoids

2024-10-07

Abstract excerpt

<h4>Summary</h4> Apolipoprotein E4 ( APOE4 ) is the leading genetic risk factor for Alzheimer’s disease. While most studies examine the role of APOE4 in aging, imaging, and cognitive assessments reveal that APOE4 influences brain structure and function as early as infancy. Here, we examined human-relevant cellular phenotypes across neurodevelopment using induced pluripotent stem cell (iPSC) derived cortical an...

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Literature Corpus work: ec297880-5436-51b8-a5c2-b2b253faa858
DOI: 10.1101/2024.10.07.617044

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