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Article

Altered network properties in C9ORF72 repeat expansion cortical neurons are due to synaptic dysfunction.

Molecular neurodegeneration - 4 Mar 2021

Perkins Emma M, Burr Karen, Banerjee Poulomi, Mehta Arpan R, Dando Owen, Selvaraj Bhuvaneish T, Suminaite Daumante, Nanda Jyoti, Henstridge Christopher M, Gillingwater Thomas H, Hardingham Giles E, Wyllie David J A, Chandran Siddharthan, Livesey Matthew R

Abstract excerpt

BACKGROUND: Physiological disturbances in cortical network excitability and plasticity are established and widespread in amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) patients, including those harbouring the C9ORF72 repeat expansion (C9ORF72RE) mutation - the most common genetic impairment causal to ALS and FTD. Noting that perturbations in cortical function are evidenced...

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Identifiers

PMID: 33663561
DOI: 10.1186/s13024-021-00433-8
PMCID: PMC7931347

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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