Article

Time-Resolved Neuronal Network Dynamics Distinguish Pathological States in Organoid Models

2026-03-26

Abstract excerpt

<h4>ABSTRACT</h4> Human brain assembloids offer a powerful platform for modeling neurological diseases, yet comprehensive methods for analyzing their complex network dynamics are lacking. Here, we developed a time-resolved network analysis pipeline that extracts quantitative biomarkers from two-photon calcium imaging, enabling the detection of subtle differences between disease and control models. We applied this...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 836e892d-b0a8-5145-8770-e353b2a11e04
DOI: 10.64898/2026.03.25.714227

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Time-Resolved Neuronal Network Dynamics Distinguish Pathological States in Organoid ModelsDOI 10.64898/2026.03.25.714227Read

Identification of neural oscillations and epileptiform changes in human brain organoidsSemantic proximity Read

Structural and Synaptic Dysregulation Drives Network Vulnerability in APOE4 Human Neuronal NetworksSemantic proximity Read

Molecular analysis of network vulnerability to α-synuclein pathology reveals PAKs as therapeutic targets for Parkinson’s diseaseSemantic proximity Read

Cerebral cortical functional hyperconnectivity in a mouse model of spinocerebellar ataxia type 8 (SCA8)Semantic proximity Read

Conserved cell-type specific signature of resilience to Alzheimer’s disease nominates role for excitatory intratelencephalic cortical neuronsSemantic proximity Read

Early Alzheimer’s disease pathology in human cortex is associated with a transient phase of distinct cell statesSemantic proximity Read

The ENIGMA Toolbox: Cross-disorder integration and multiscale neural contextualization of multisite neuroimaging datasetsSemantic proximity Read

Network-based atrophy modelling in the common epilepsies: a worldwide ENIGMA studySemantic proximity Read

Edge-Centric Control Energy Follows an Inverted-U Trajectory Through Alzheimer’s Disease ProgressionSemantic proximity Read

Structural and functional alterations associated with the LRRK2 G2019S mutation revealed in structured human neural networksSemantic proximity Read

Multi-Transcriptomic Analysis Points to Early Organelle Dysfunction in Human Astrocytes in Alzheimer’s DiseaseSemantic proximity Read

Whole-brain cellular-resolution functional network properties of seizure susceptibilitySemantic proximity Read