Article

Molecular and neuropathological determinants of neuronal dysfunction in Alzheimer’s disease

2025-10-09

Abstract excerpt

The biological basis of neuronal excitatory/inhibitory (E/I) imbalance in Alzheimer’s disease (AD) remains unclear. Using a comprehensive cohort with ante-mortem functional neuroimaging and post-mortem molecular data from the same participants, we mapped individual, whole-brain E/I imbalances through biophysical modeling. E/I ratios in regions supporting higher-order cognitive functions were significantly associat...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 9782f73d-98c9-53e7-94b6-8c184b29ba33
DOI: 10.1101/2025.10.08.681211

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Molecular and neuropathological determinants of neuronal dysfunction in Alzheimer’s diseaseDOI 10.1101/2025.10.08.681211Read

Transcriptomic signatures of Aβ- and tau-induced neuronal dysfunction reveal inflammatory processes at the core of Alzheimer’s disease pathophysiologySemantic proximity Read

Early Alzheimer’s disease pathology in human cortex is associated with a transient phase of distinct cell statesSemantic proximity Read

Molecular properties underlying regional vulnerability to Alzheimer's disease pathology.Semantic proximity Read

Elucidating the neuropathological and molecular heterogeneity of amyloid-beta and tau in Alzheimer's disease through machine learning and transcriptomic integrationSemantic proximity Read

Novel Pathological Mechanisms Revealed by Spatial Transcriptomic Analysis of Hippocampus in Aged Control, Primary Age-Related Tauopathy, and Alzheimer’s DiseaseSemantic proximity Read

Consistent Genes Associated With Structural Changes in Clinical Alzheimer’s Disease SpectrumSemantic proximity Read

Proteomic Subtyping of Alzheimer’s Disease CSF links Blood-Brain Barrier Dysfunction to Reduced levels of Tau and Synaptic BiomarkersSemantic proximity Read

Genome-wide association study of brain biochemical phenotypes reveals distinct genetic architecture of Alzheimer’s Disease related proteinsSemantic proximity Read

Genomic partitioning of Alzheimer’s disease in humans reveals non-CNS etiologySemantic proximity Read

Leveraging selective hippocampal vulnerability among Alzheimer’s disease subtypes reveals a novel tau binding partner SERPINA5Semantic proximity Read

Transcriptomic profiling of the middle temporal gyrus reveals differential glial/neuronal dysregulation across Alzheimer’s disease and agingSemantic proximity Read

Whole-Brain Cell-Cell Interaction Axes Explaining Tissue Vulnerability Across the Neurodegenerative SpectrumSemantic proximity Read