Article

Condensate-Driven Triglyceride Depletion Links α-Synuclein to Mitochondrial Dysfunction

2025-10-23

Abstract excerpt

<h4>Summary</h4> Inclusions of α-Synuclein (αSyn) characterize multiple age-related neurodegenerative diseases, including Parkinson’s disease (PD) and Multiple System Atrophy (MSA). While interactions between αSyn and lipids are known to contribute to αSyn pathobiology, the precise cellular mechanisms that link lipids to αSyn toxicity have yet to be elucidated. Through lipidomic profiling of Caenorhabditis elega...

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Literature Corpus work: 7f0ee64b-cf53-5883-9e29-1f878f03e4e3
DOI: 10.1101/2025.10.22.682553

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